Tropanyl-3,5-dimethylbenzoate

Product details

• Chemical name: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dimethylbenzoate.
• CAS number: 85181-40-4
• Molecular formula: C17H23NO2.
• Purity: >99%
• Concentration: 1 nM - 1 µM.
• Form: Lyophilized Powder
• Solubility: 50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: 50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: 5-HT3 receptors
• Source: Synthetic
• Activity: Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist1.

Scientific background

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Tropanyl-3,5-dimethylbenzoate is a synthetic, potent and selective antagonist of the 5-HT3 receptor. Tropanyl-3,5-dimethylbenzoate has an effective concentration of 1 nM - 1 μM. Interestingly, in rat mucosa and submucosa preparations Tropanyl causes an increase of 5-HT induced Δ/sc (change in short circuit current) and causes a decline of Δ/sc in rat intact colon suggesting a double role for 5-HT3 receptors in this tissue2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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