| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 1H-indole-3-carboxylate;hydrochloride.
- CAS number: 105826-92-4
- Molecular formula: C17H21ClN2O2.
- Purity: >98%
- Concentration: 0.1-10 nM.
- Form: Lyophilized Powder
- Solubility: 50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 50 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-Hydroxytryptamine Receptor 3A
- Source: Synthetic
- Activity: Tropisetron hydrochloride is a potent and selective 5-HT3A channel blocker with Ki ~ 2 nM1.
Scientific background
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Tropisetron hydrochloride is a synthetic, potent and selective antagonist of 5-HT3A channel. In fluorescence polarization it was found to have an affinity 8.31 pKi (M) for 5-HT3A receptor2. Tropisetron binds to an extracellular domain of the receptor. Tropisetron was found to have an analgesic and anti-inflammatory activity via inhibition of lipopolysaccharide (LPS) stimulated tumor necrosis factor (TNF) and interleukin-1-β release from human monocytes. This inhibition is conducted by preventing the phosphorylation of the p38 mitogen activated kinase (MAPK)3. Interestingly, when combined with acetaminophen in an experimental pain inducing assay, Tropisetron blocked the analgesic effect of acetaminophen thus indicating that perhaps the analgesic action of acetaminophen is also mediated through 5-HT receptors4.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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