| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H19FN2O4 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Tubulin/HDAC-IN-2 (Compound II-19k) dually inhibits Tubulin and HDAC, with IC50 values of 0.403 μM, 0.591 μM, 3.552 μM and 0.459 μM against HDAC1, HDAC2, HDAC3 and HDAC6, respectively. It arrests the cell cycle at G2 phase, induces apoptosis, and inhibits the growth of hematoma and solid tumor cells, reducing tumor metastasis and slowing tumor growth in a liver tumor allograft mouse model[1]. It has the molecular formula C21H19FN2O4 and a molecular weight of 382.38 g/mol.
Physical & Chemical Properties
| CAS Number | 3049740-77-1 |
|---|---|
| Molecular Formula | C21H19FN2O4 |
| Molecular Weight | 382.38 g/mol |
| SMILES | O=C(NO)C(F)OC1=CC(C(C2=CC(C)=NC3=CC=CC=C23)=C)=CC=C1OC |
| Signaling Pathway | Cell Cycle/DNA Damage; Apoptosis; Epigenetics; Cytoskeleton |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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