| Field | Specification |
|---|---|
| Alternative names | Tunicamycin from Streptomyces sp. |
| CAS no. | |
| Applications | |
| Source | Isolated from Streptomyces lysosuperficus |
| Molecular weight | |
| Molecular formula | C39H64N4O16 |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble in DMSO (>10 mg/ml) or ethanol (5 mg/ml; warm). |
| SMILES | |
| Form | White solid. |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Tunicamycin is an antibiotic that inhibits N-linked glycosylation by blocking the formation of N-acetylglucosamine-lipid intermediates. This disruption leads to ER stress and activation of the unfolded protein response (UPR). In neuroscience, Tunicamycin is used to model ER stress and study its effects on neuronal survival, protein folding, and neuroinflammation. It is particularly relevant in Alzheimer’s and Parkinson’s disease research, where ER dysfunction and protein misfolding are central pathological features.
Classification: D1A- Very Toxic Material Causing Immediate and Serious Toxic Effects, Highly toxic by ingestion, D2A- Very Toxic Material Causing Other Toxic Effects, Teratogen- Reproductive hazard
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H300- Fatal if swallowed.
Precautionary statements:
- P264- Wash hands thoroughly after handling.
- P301 + P310- IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
Tunicamycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-397)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Ding W.X., et al. (2007) J Biol Chem. 282(7): 4702-10.
3. Ishii S., et al. (1987) J Neurochem. 49(5): 1606-12.
4. Zhang J., et al. (2013) J Surg Res. 183(2): 929-35. 5. Coppola-Segovia V., et al. (2016) Molecular Neuro. 54, 5798-5806.
