| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Apocynaceae Tylophora ovata (Lindl.) Hook. ex Steud. |
| Molecular weight | |
| Molecular formula | C28H38O10 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Tylogenin is a Na+/K+ ATPase inhibitor with an IC50 of 93.3 μM against rabbit-derived targets. It inhibits antigen-induced mediator release from rabbit basophils and IgE-dependent histamine release from human leukocytes, exhibiting antiallergic activity, and it can be used in research related to allergic diseases[1][2][3]. It has a molecular formula of C28H38O10 and a molecular weight of 534.60 g/mol.
Physical & Chemical Properties
| CAS Number | 135247-46-0 |
|---|---|
| Molecular Formula | C28H38O10 |
| Molecular Weight | 534.60 g/mol |
| Structure Classification | Terpenoids Triterpenes |
| SMILES | C[C@]12[C@@]([C@H](C(CC2)=O)OC(C)=O)([H])[C@H](C[C@]3([H])[C@]1([H])CC[C@@]([C@@H]3OC(C)=O)(C([C@@](C)(O4)OC)=CC4=O)C)OC(C)=O |
| Signaling Pathway | Membrane Transporter/Ion Channel |
| Initial Source | Plant — Apocynaceae Tylophora ovata (Lindl.) Hook. ex Steud. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Gnabre, Jean-Noel. Antiallergic activity of Tylophora sylvatica. The University of Arizona.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In the BDSR assay, Tylogenin (1-300 μM; 15-120 min) inhibits antigen-induced serotonin release from sensitized rabbit basophils in a time-dependent manner, with an IC50 of 38.90 μM after 120 min of incubation; inhibition reaches 92% at 300 μM after 120 min of incubation[1]. In the LDHR assay, Tylogenin at 1-300 μM (4 h) inhibits antigen-induced Histamine release from leukocytes of atopic individuals, with an IC50 of 48.98 μM[1]. The activity of Na+/K+ ATPase in rabbit renal cortical basolateral membrane vesicles is inhibited by Tylogenin (5-2000 μM; 1 h), with an IC50 of 93.3 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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