| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine.
- CAS number: 153436-53-4
- Molecular formula: C16H14ClN3O2.
- Purity: >99%
- Concentration: 0.5-50 µM.
- Form: Lyophilized powder.
- Solubility: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: EGF Receptor Tyrosine Kinase
- Source: Synthetic
- Activity: Tyrphostin AG 1478 is a reversible, highly potent and selective blocker of EGF receptor tyrosine kinase (IC50 = 3 nM)1. At higher concentrations, it also inhibits KV1.5 K+ channels in an EGF receptor-independent manner (IC50 = 9.8 µM)2.
Scientific background
Tyrphostin AG 1478 (AG 1478) is a reversible, highly potent (IC50 = 3 nM) and selective inhibitor of EGFR tyrosine kinase activity, commonly used as an EGF signaling blocker.1AG 1478 inhibits cell proliferation and arrests the cell cycle in tumor cells with overexpression of EGFR.2,3AG1478 also directly blocks (IC50 = 9.8 µM) the rat brain KV1.5 K+ channel in vitro in a non-protein-tyrosine-kinase-mediated manner.4
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
