| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 21-{4-[2,6-Di(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl}pregna-1,4,9(11)-triene-3,20-dione (2Z)-2-butenedioate (1:1) |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 25 mg/ml DMSO, and in 20 mg/ml in ethanol; Insoluble in water |
| Source | Synthetic |
| Storage |
U-74389G is a potent antioxidant that prevents iron-dependent lipid peroxidation, a key contributor to neuronal damage in ischemia-reperfusion injury. It has been studied for its protective effects in organ preservation and reperfusion models. In neuroscience, U-74389G is of interest for its ability to reduce oxidative stress and preserve neuronal integrity in models of stroke and traumatic brain injury. Its mechanism of action involves stabilizing cell membranes and preventing lipid peroxidation-induced apoptosis.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
U-74389G (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-205)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Perna A.M., et al. (1996) Pharmacol Res. 34: 25-31.
3. Palma-Vargas J.M., et al. (1996) J Surg Res. 66: 131-137.
4. Shoskes D.A., Xie Y., Gonzalez-Cadavid N.F. Transplantation. 63: 495-500.
