U-Blot® ABCBB Rabbit Polyclonal Antibody

SKU:BHA21804271
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    Overview
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    Anti-ABCBB antibody (Rabbit host, polyclonal, Unconjugated). Validated for Western Blot, ELISA with reactivity to Human, Rat, Mouse.
    Clonality Polyclonal
    Host Rabbit
    Reactivity Human, Rat, Mouse
    Conjugate Unconjugated
    Isotype IgG
    Applications Western Blot, ELISA
    Options selector
    Catalog no. Size
    WP0932-50 50 uL
    WP0932-100 100 uL
    Available Options

    Select the variant that best fits your experiment. Availability and lead time may vary by option.

    • Options: Size: 50 uL
    • Lead time: options listed in "Availability Content"; other statuses may take longer.
    • Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
    • Shipping: cold-chain shipment (typically with ice packs).
    • Upon receipt: store at recommended temperature as soon as possible.
    • Sales terms and conditions: Please review prior to ordering.
    Field Specification
    Antigen
    • Bile salt export pump (ATP-binding cassette sub-family B member 11)
    Cellular Localization Apical cell membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Endosome . Cell membrane ; Multi-pass membrane protein . Internalized at the canalicular membrane through interaction with the adapter protein complex 2 (AP-2) (PubMed:22262466). At steady state, localizes in the canalicular membrane but is also present in recycling endosomes. ABCB11 constantly and rapidly exchanges between the two sites through tubulo-vesicles carriers that move along microtubules. Microtubule-dependent trafficking of ABCB11 is enhanced by taurocholate and cAMP and regulated by STK11 through a PKA-mediated pathway. Trafficking of newly synthesized ABCB11 through endosomal compartment to the bile canalicular membrane is accelerated by cAMP but not by taurocholate (By similarity). Cell membrane expression is up-regulated by short- and medium-chain fatty acids (PubMed:20398791). .
    Clonality
    • Polyclonal
    Concentration 1 mg/ml
    Conjugate
    • Unconjugated
    Formulation PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    Gene ID 8647 (Human)
    Host Rabbit
    Immunogen Synthesized peptide derived from part region of human protein
    Isotype
    • IgG
    Molecular Weight Observed: 145 kDa
    Product Type
    • Polyclonal Antibody
    • Primary Antibodies
    Reactivity
    • Human
    • Rat
    • Mouse
    Storage -15°C to -25°C/1 year(Do not lower than -25°C)
    Target ABCBB
    Antibody

    Product Overview

    U-Blot® ABCBB Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against ABCBB. It has been validated for Western Blot, ELISA and reacts with Human, Rat, Mouse.

    Validated Applications

    Target ABCBB
    Host Rabbit
    Clonality Polyclonal
    Isotype IgG
    Conjugate Unconjugated
    Reactivity Human, Rat, Mouse
    Applications Western Blot, ELISA
    Purification Affinity Purified
    Specificity ABCBB Polyclonal Antibody detects endogenous levels of protein.
    Molecular Weight Observed: 145 kDa
    UniProt / Swiss-Prot O95342 (Human) | Q9QY30 (Mouse) | O70127 (Rat)

    Recommended dilutions: WB 1:500-2000;ELISA 1:5000-20000

    Immunogen / Antigen

    Synthesized peptide derived from part region of human protein

    Reactivity Notes

    Confirmed cross-reactivity: Human, Rat, Mouse. Confirm suitability for untested species before use.

    Scientific Background

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

    Safety & Handling

    For Research Use Only (RUO). Not for diagnostic or therapeutic use. Store as indicated: -15°C to -25°C/1 year(Do not lower than -25°C)
    What applications is this antibody validated for?

    This antibody is validated for Western Blot, ELISA. Recommended dilutions: WB 1:500-2000;ELISA 1:5000-20000

    What species does it react with?

    Confirmed reactivity: Human, Rat, Mouse. Other species should be validated by the user.

    Is this antibody conjugated?

    Conjugate: Unconjugated.

    How should it be stored?

    Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)

    Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.

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