| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | ABCG2;ABCP;BCRP;BCRP1;MXR;ATP-binding cassette sub-family G member 2;Breast cancer resistance protein;CDw338;Mitoxantrone resistance-associated protein;Placenta-specific ATP-binding cassette transporter;CD338 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human ABCG2. AA range:461-510 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® ABCG2 Rabbit Polyclonal Antibody (WP15566) is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against ABCG2. It has been validated for Immunofluorescence, Western Blot, Immunohistochemistry, ELISA and reacts with Human, Rat, Mouse.
Validated Applications
| Target | ABCG2 |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Rat, Mouse |
| Applications | Immunofluorescence, Western Blot, Immunohistochemistry, ELISA |
| Purification | Affinity Purified |
| Specificity | ABCG2 Polyclonal Antibody detects endogenous levels of ABCG2 protein. |
| Molecular Weight | Observed: 75 kDa |
| UniProt / Swiss-Prot | Q9UNQ0 (Human) | Q7TMS5 (Mouse) |
Recommended dilutions: IF 1:50-200;WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;Not yet tested in other applications
Immunogen / Antigen
The antiserum was produced against synthesized peptide derived from the Internal region of human ABCG2. AA range:461-510
Reactivity Notes
Confirmed cross-reactivity: Human, Rat, Mouse. Confirm suitability for untested species before use.
Scientific Background
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Safety & Handling
This antibody is validated for Immunofluorescence, Western Blot, Immunohistochemistry, ELISA. Recommended dilutions: IF 1:50-200;WB 1:500-1:2000;IHC: 1:100-1:300;ELISA 1:10000;Not yet tested in other applications
Confirmed reactivity: Human, Rat, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
