| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | Amyloid beta A4 protein;ABPP;APPI;APP;Alzheimer disease amyloid protein;Cerebral vascular amyloid peptide;CVAP;PreA4;Protease nexin-II;PN-II;[Cleaved into: N-APP;Soluble APP-alpha;S-APP-alpha;Soluble APP-beta;S-APP-beta;C99;Beta-amyloid protein 42;Beta-APP42;Beta-amyloid protein 40;Beta-APP40;C83;P3;42;P3;40;C80;Gamma-secretase C-terminal fragment 59;Amyloid intracellular domain 59;AICD-59;AID;59;Gamma-CTF;59;Gamma-secretase C-terminal fragment 57;Amyloid intracellular domain 57;AICD-57;AID;57;Gamma-CTF;57;Gamma-secretase C-terminal fragment 50;Amyloid intracellular domain 50;AICD-50;AID;50;Gamma-CTF;50;C31] |
| Gene ID | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Synthesized peptide derived from Amyloid-β at AA range: 631-680 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Amyloid-β Rabbit Polyclonal Antibody (WP15742) is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against Amyloid-β. It has been validated for Western Blot, Immunofluorescence, ELISA and reacts with Human, Rat, Mouse.
Validated Applications
| Target | Amyloid-β |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Rat, Mouse |
| Applications | Western Blot, Immunofluorescence, ELISA |
| Purification | Affinity Purified |
| Specificity | Amyloid-β Polyclonal Antibody detects endogenous levels of Amyloid-β |
| Molecular Weight | Observed: 86 kDa,45 kDa |
| UniProt / Swiss-Prot | P05067 (Human) | P12023 (Mouse) |
Recommended dilutions: WB 1:500-2000;IF/ICC1:100-500;ELISA 1:5000-20000
Immunogen / Antigen
Synthesized peptide derived from Amyloid-β at AA range: 631-680
Reactivity Notes
Confirmed cross-reactivity: Human, Rat, Mouse. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence, ELISA. Recommended dilutions: WB 1:500-2000;IF/ICC1:100-500;ELISA 1:5000-20000
Confirmed reactivity: Human, Rat, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
