U-Blot® APPL2 Rabbit Polyclonal Antibody

SKU:BHA21819600
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    Overview
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    Anti-APPL2 antibody (Rabbit host, polyclonal, Unconjugated). Validated for Western Blot with reactivity to Human, Mouse.
    Clonality Polyclonal
    Host Rabbit
    Reactivity Human, Mouse
    Conjugate Unconjugated
    Isotype IgG
    Applications Western Blot
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    Options selector
    Catalog no. Size
    WP8322-50 50 uL
    WP8322-100 100 uL
    Available Options

    Select the variant that best fits your experiment. Availability and lead time may vary by option.

    • Options: Size: 50 uL
    • Lead time: options listed in "Availability Content"; other statuses may take longer.
    • Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
    • Shipping: cold-chain shipment (typically with ice packs).
    • Upon receipt: store at recommended temperature as soon as possible.
    • Sales terms and conditions: Please review prior to ordering.
    Field Specification
    Antigen
    • DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain
    • PTB domain and leucine zipper motif 2)
    Cellular Localization Early endosome membrane ; Peripheral membrane protein . Nucleus . Cell membrane . Endosome membrane . Cytoplasm . Cytoplasmic vesicle, phagosome . Cell projection, ruffle . Cell projection, ruffle membrane . Cell membrane . Cytoplasmic vesicle, phagosome membrane . Early endosomal membrane-bound and nuclear (PubMed:15016378). Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (PubMed:15016378). Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events (PubMed:18034774). PI(4,5)P2 levels are important for membrane association of APPL2 (PubMed:18034774). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome (By similarity). Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (By similarity). .
    Clonality
    • Polyclonal
    Concentration 1 mg/ml
    Conjugate
    • Unconjugated
    Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Gene ID 55198 (Human) | 216190 (Mouse)
    Host Rabbit
    Immunogen Synthesized peptide derived from human APPL2
    Isotype
    • IgG
    Molecular Weight Calculated: 73 kDa
    Product Type
    • Polyclonal Antibody
    • Primary Antibodies
    Reactivity
    • Human
    • Mouse
    Storage -15°C to -25°C/1 year(Do not lower than -25°C)
    Target APPL2
    Antibody

    Product Overview

    U-Blot® APPL2 Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against APPL2. It has been validated for Western Blot and reacts with Human, Mouse.

    Validated Applications

    Target APPL2
    Host Rabbit
    Clonality Polyclonal
    Isotype IgG
    Conjugate Unconjugated
    Reactivity Human, Mouse
    Applications Western Blot
    Purification Affinity Purified
    Specificity This antibody detects endogenous levels of APPL2 at Human, Mouse
    Molecular Weight Calculated: 73 kDa
    UniProt / Swiss-Prot Q8NEU8 (Human) | Q8K3G9 (Mouse)

    Recommended dilutions: WB 1:500-2000

    Immunogen / Antigen

    Synthesized peptide derived from human APPL2

    Reactivity Notes

    Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.

    Safety & Handling

    For Research Use Only (RUO). Not for diagnostic or therapeutic use. Store as indicated: -15°C to -25°C/1 year(Do not lower than -25°C)
    What applications is this antibody validated for?

    This antibody is validated for Western Blot. Recommended dilutions: WB 1:500-2000

    What species does it react with?

    Confirmed reactivity: Human, Mouse. Other species should be validated by the user.

    Is this antibody conjugated?

    Conjugate: Unconjugated.

    How should it be stored?

    Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)

    Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.

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