| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | B-cell lymphoma 6 protein;BCL-6;B-cell lymphoma 5 protein;BCL-5;Protein LAZ-3;Zinc finger and BTB domain-containing protein 27;Zinc finger protein 51 |
| Gene ID | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Synthesized peptide derived from human Bcl-6 (Acetyl Lys379) |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Bcl-6 (Acetyl Lys379) Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against Bcl-6. Recognizes Acetyl. It has been validated for Western Blot, ELISA and reacts with Human, Mouse, Rat.
Validated Applications
| Target | Bcl-6 |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Western Blot, ELISA |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of Human,Mouse,Rat Bcl-6 (Acetyl Lys379) |
| Molecular Weight | Observed: 80 kDa |
| UniProt / Swiss-Prot | P41182 (Human) | P41183 (Mouse) |
Recommended dilutions: WB 1:1000-2000;ELISA 1:5000-20000
Immunogen / Antigen
Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.
Safety & Handling
This antibody is validated for Western Blot, ELISA. Recommended dilutions: WB 1:1000-2000;ELISA 1:5000-20000
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
