| Field | Specification |
|---|---|
| Alternative Names | ARB 1;ARB 1;ARB1;ARB1;ARR 1;ARR 1;ARR1;ARR1;ARRB 1;ARRB1;ARRB1;ARRB1_HUMAN;Arrestin 2;Arrestin beta 1;Arrestin beta-1;Beta-arrestin-1. |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli. |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® β-Arrestin 1 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Arrestin 1. It has been validated for Western Blot and reacts with Mouse, Rat, Human.
Validated Applications
| Target | Arrestin 1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Mouse, Rat, Human |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of beta Arrestin 1 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 50 kDa |
| UniProt / Swiss-Prot | P49407 (Human) | Q8BWG8 (Mouse) |
Recommended dilutions: WB 1:500
Immunogen / Antigen
Purified recombinant human beta Arrestin 1 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Mouse, Rat, Human. Confirm suitability for untested species before use.
Scientific Background
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:500
Confirmed reactivity: Mouse, Rat, Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
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