| Field | Specification |
|---|---|
| Target | |
| Alternative names | Agammaglobulinaemia tyrosine kinase;AGMX 1;AGMX1;AT;ATK;B cell progenitor kinase;B-cell progenitor kinase;BPK;Bruton agammaglobulinemia tyrosine kinase;Bruton tyrosine kinase;Bruton’s Tyrosine Kinase;Btk;BTK_HUMAN;IMD 1;IMD1;MGC126261;MGC126262;OTTHUMP00000063593;PSCTK 1;PSCTK1;Tyrosine protein kinase BTK;Tyrosine-protein kinase BTK;XLA |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human BTK protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® BTK Mouse Monoclonal Antibody (WM0622) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against BTK. It has been validated for Western Blot, Immunoprecipitation and reacts with Human.
Validated Applications
| Target | BTK |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot, Immunoprecipitation |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of BTK and does not cross-react with related proteins. |
| Molecular Weight | Observed: 77 kDa |
| UniProt / Swiss-Prot | Q06187 (Human) | P35991 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human BTK protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Safety & Handling
This antibody is validated for Western Blot, Immunoprecipitation. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
