| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Interleukin-6 receptor subunit beta;IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB;CDw130;Interleukin-6 signal transducer;Membrane glycoprotein 130;gp130;Oncostatin-M receptor subunit alpha;CD antigen CD130 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human CD130/gp130 (Phospho-Ser782) |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® CD130/gp130 (Phospho Ser782) Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against CD130/gp130. Recognizes Phospho. It has been validated for Immunohistochemistry, Immunofluorescence, Western Blot and reacts with Human, Mouse.
Validated Applications
| Target | CD130/gp130 |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse |
| Applications | Immunohistochemistry, Immunofluorescence, Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous phospho levels of CD130/gp130 (Phospho-Ser782) at Human:S782, Mouse:S780 |
| Molecular Weight | Observed: 130 kDa |
| UniProt / Swiss-Prot | P40189 (Human) |
Recommended dilutions: IHC 1:50-200;WB 1:500-2000;IF 1:50-200
Immunogen / Antigen
Synthesized peptide derived from human CD130/gp130 (Phospho-Ser782)
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
Safety & Handling
This antibody is validated for Immunohistochemistry, Immunofluorescence, Western Blot. Recommended dilutions: IHC 1:50-200;WB 1:500-2000;IF 1:50-200
Confirmed reactivity: Human, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
