| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | TLR4;Toll-like receptor 4;hToll;CD antigen CD284 |
| Gene ID | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human CD284 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® CD284/TLA4 (PTR1381) recombinant Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against CD284. It has been validated for Flow Cytometry, ELISA and reacts with Human.
Validated Applications
| Target | CD284 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | PTR1381 |
| Isotype | IgG1, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Flow Cytometry, ELISA |
| Purification | Affinity Purified |
| Specificity | This recombinant monoclonal antibody can detects endogenous levels of CD284 protein. |
| Molecular Weight | Observed: 95 kDa |
| UniProt / Swiss-Prot | O00206 (Human) | Q9QUK6 (Mouse) |
Recommended dilutions: ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
Immunogen / Antigen
Purified recombinant human CD284
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Safety & Handling
This antibody is validated for Flow Cytometry, ELISA. Recommended dilutions: ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone PTR1381.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
