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| Reactivity | |
| Applications | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 380-460 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
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Product Overview
U-Blot® COX1 Rabbit Polyclonal Antibody (WP0605) is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against COX1. It has been validated for Western Blot, ELISA and reacts with Human, Mouse.
Validated Applications
| Target | COX1 |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse |
| Applications | Western Blot, ELISA |
| Purification | Affinity Purified |
| Specificity | COX1 Polyclonal Antibody detects endogenous levels of protein. |
| Molecular Weight | Observed: 56 kDa |
| UniProt / Swiss-Prot | P00395 (Human) | P00397 (Mouse) | P05503 (Rat) |
Recommended dilutions: WB 1:500-2000;ELISA 1:5000-20000
Immunogen / Antigen
Synthesized peptide derived from human protein . at AA range: 380-460
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.
Scientific Background
catalytic activity:4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.,disease:Defects in MT-CO1 are a cause of anemia sideroblastic acquired idiopathic (AISA) [MIM:516030]; a disease characterized by inadequate formation of heme and excessive accumulation of iron in mitochondria.,disease:Defects in MT-CO1 are a cause of cytochrome c oxidase deficiency (COX deficiency) [MIM:220110]; also called mitochondrial complex IV deficiency. COX deficiency is a clinically heterogeneous disorder. The clinical features are ranging from isolated myopathy to severe multisystem disease, with onset from infancy to adulthood.,disease:Defects in MT-CO1 are a cause of Leber hereditary optic neuropathy (LHON) [MIM:535000]. LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes.,disease:Defects in MT-CO1 are associated with recurrent myoglobinuria [MIM:550500]. Myoglobinuria consists of excretion of myoglobin in the urine.,function:Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.,pathway:Energy metabolism; oxidative phosphorylation.,similarity:Belongs to the heme-copper respiratory oxidase family.
Safety & Handling
This antibody is validated for Western Blot, ELISA. Recommended dilutions: WB 1:500-2000;ELISA 1:5000-20000
Confirmed reactivity: Human, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
