| Field | Specification |
|---|---|
| Target | |
| Alternative names | CCND 2;CCND2;CCND2_HUMAN;CyclinD2;G1/S specific cyclin D2;G1/S-specific cyclin-D2;KIAK0002;MGC102758. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human Cyclin D2 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Cyclin D2 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Cyclin D2. It has been validated for Western Blot and reacts with Human.
Validated Applications
| Target | Cyclin D2 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects over-expressed levels of Cyclin D2 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 38 kDa |
| UniProt / Swiss-Prot | P30279 (Human) | P30280 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human Cyclin D2 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencep
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
