| Field | Specification |
|---|---|
| Target | |
| Alternative names | Fas like protein;Apoptosis inducing protein TRICK2A/2B;Apoptosis inducing receptor TRAIL R2;CD 262;CD262;CD262 antigen;Cytotoxic TRAIL receptor 2;Death domain containing receptor for TRAIL/Apo 2L;Death domain containing receptor for TRAIL/Apo2L;Death receptor 5;DR 5;DR5;Fas like protein precursor;KILLER;KILLER/DR5;OTTHUMP00000123492;OTTHUMP00000123493;p53 regulated DNA damage inducible cell death receptor;killer;p53 regulated DNA damage inducible cell death receptor;killer;TNF related apoptosis inducing ligand receptor 2;TNF related apoptosis inducing ligand receptor 2;TNF-related apoptosis-inducing ligand receptor 2;TNFRSF10B;TR10B_HUMAN;TRAIL R2;TRAIL receptor 2;TRAIL-R2;TRAILR2;TRANCER;TRICK2;TRICK2A;TRICK2B;TRICKB;Tumor necrosis factor receptor like protein ZTNFR9;Tumor necrosis factor receptor like protein ZTNFR9;Tumor necrosis factor receptor superfamily member 10b;Tumor necrosis factor receptor superfamily, member 10b;ZTNFR9. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human DR5 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® DR5 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against DR5. It has been validated for Western Blot, Immunofluorescence and reacts with Human, Mouse.
Validated Applications
| Target | DR5 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse |
| Applications | Western Blot, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of DR5 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 48 kDa |
| UniProt / Swiss-Prot | O14763 (Human) | Q9QZM4 (Mouse) |
Recommended dilutions: WB 1:500-1:2000;ICC 1:100
Immunogen / Antigen
Purified recombinant human DR5 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence. Recommended dilutions: WB 1:500-1:2000;ICC 1:100
Confirmed reactivity: Human, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
