| Field | Specification |
|---|---|
| Target | |
| Alternative names | FADD;FADD protein;FADD_HUMAN;Fas;TNFRSF6;associated via death domain;Fas associated via death domain;Fas associating death domain containing protein;Fas associating death domain containing protein;Fas associating protein;Fas associating protein with death domain;Fas associating protein with death domain;Fas TNFRSF6 associated via death domain;FAS-associated death domain protein;FAS-associating death domain-containing protein;FasTNFRSF6 associated via death domain;FasTNFRSF6 associated via death domain;GIG 3;GIG3;Growth inhibiting gene 3 protein;Growth-inhibiting gene 3 protein;H sapiens mRNA for mediator of receptor induced toxicity;H sapiens mRNA for mediator of receptor induced toxicity;Mediator of receptor induced toxicity;Mediator of receptor induced toxicity;MGC8528;MGC8528;MORT 1;MORT1;MORT1;Protein FADD. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human FADD protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® FADD Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against FADD. It has been validated for Western Blot and reacts with Human.
Validated Applications
| Target | FADD |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of FADD and does not cross-react with related proteins. |
| Molecular Weight | Observed: 23 kDa |
| UniProt / Swiss-Prot | Q13158 (Human) | Q61160 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human FADD protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
