| Field | Specification |
|---|---|
| Target | |
| Alternative names | Abundant SRC homology;Adapter protein GRB2;ASH;Ash protein;EGFRBP GRB2;Epidermal growth factor receptor binding protein;Epidermal growth factor receptor binding protein GRB2;GRB 2;GRB2 adapter protein;Grb2;GRB2_HUMAN;Grb3 3;Growth factor receptor bound protein 2;Growth factor receptor bound protein 3;Growth factor receptor-bound protein 2;HT027;MST084;MSTP084;NCKAP2;OTTHUMP00000166096;OTTHUMP00000166097;OTTHUMP00000166098;Protein ASH;SEM5;SH2/SH3 adapter GRB2. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Recombinant protein of human GRB2. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® GRB2 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against GRB2. It has been validated for Western Blot and reacts with Human, Mouse, Rat.
Validated Applications
| Target | GRB2 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of GRB2 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 25 kDa |
| UniProt / Swiss-Prot | P62993 (Human) | Q60631 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Recombinant protein of human GRB2.
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
