| Field | Specification |
|---|---|
| Target | |
| Alternative names | CBX 3;CBX3;CBX3_HUMAN;Chromobox homolog 3;HP1 gamma homolog, Drosophila;Chromobox homolog 3;Chromobox protein homolog 3;GAMMA;HECH;Heterochromatin like protein 1;Heterochromatin protein 1 homolog gamma;Heterochromatin protein HP1 gamma;HP1 gamma;HP1 gamma homolog;HP1Hs gamma;Modifier 2 protein. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human HP1-gamma protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® HP1-γ Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against HP1γ. It has been validated for Western Blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry and reacts with Mouse, Human, Monkey, Hamster, Rat.
Validated Applications
| Target | HP1γ |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Mouse, Human, Monkey, Hamster, Rat |
| Applications | Western Blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of HP1-gamma and does not cross-react with related proteins. |
| Molecular Weight | Observed: 22 kDa |
| UniProt / Swiss-Prot | Q13185 (Human) | P23198 (Mouse) |
Recommended dilutions: WB 1:1000;ICC 1:200;IF 1:50-200
Immunogen / Antigen
Purified recombinant human HP1-gamma protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Mouse, Human, Monkey, Hamster, Rat. Confirm suitability for untested species before use.
Scientific Background
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry. Recommended dilutions: WB 1:1000;ICC 1:200;IF 1:50-200
Confirmed reactivity: Mouse, Human, Monkey, Hamster, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
