| Field | Specification |
|---|---|
| Target | |
| Alternative names | AI849689;c Jun N terminal kinase 1;C-JUN kinase 1;c-Jun N-terminal kinase 1;JAK 1A;JAK1A;JNK 1;JNK 46;JNK;JNK-46;JNK1A2;JNK21B1/2;MAP kinase 8;MAPK 8;MAPK8;Mitogen activated protein kinase 8;Mitogen-activated protein kinase 8;MK08_HUMAN;p54 gamma;PRKM 8;PRKM8;Protein kinase JNK1;Protein kinase, mitogen-activated, 8;SAPK 1;SAPK gamma;SAPK1;Stress activated protein kinase JNK1;Stress-activated protein kinase 1;Stress-activated protein kinase JNK1;Tyrosine protein kinase JAK1 . |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human JNK1 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® JNK1 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against JNK1. It has been validated for Western Blot, Immunofluorescence and reacts with Human, Mouse, Rat.
Validated Applications
| Target | JNK1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Western Blot, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of JNK1 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 46,54 kDa |
| UniProt / Swiss-Prot | P45983 (Human) | Q91Y86 (Mouse) |
Recommended dilutions: WB 1:1000;ICC 1:100;IF 1:50-200
Immunogen / Antigen
Purified recombinant human JNK1 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spl
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence. Recommended dilutions: WB 1:1000;ICC 1:100;IF 1:50-200
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
