| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | Mitogen-activated protein kinase 9;MAP kinase 9;MAPK 9;JNK-55;Stress-activated protein kinase 1a;SAPK1a;Stress-activated protein kinase JNK2;c-Jun N-terminal kinase 2 |
| Gene ID | |
| Host | |
| Clone | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Synthesized peptide derived from human JNK2 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® JNK2 Mouse Monoclonal Antibody (4D2) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against JNK2. It has been validated for Immunohistochemistry and reacts with Human, Mouse, Rat.
Validated Applications
| Target | JNK2 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4D2 |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Immunohistochemistry |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of JNK2 at Human, Mouse,Rat |
| Molecular Weight | Observed: 46,54 kDa |
| UniProt / Swiss-Prot | P45984 (Human) | Q9WTU6 (Mouse) | P49186 (Rat) |
Recommended dilutions: IHC 1:50-200
Immunogen / Antigen
Synthesized peptide derived from human JNK2
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternative
Safety & Handling
This antibody is validated for Immunohistochemistry. Recommended dilutions: IHC 1:50-200
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone 4D2.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
