| Field | Specification |
|---|---|
| Target | |
| Alternative names | 70 kDa lamin;Cardiomyopathy dilated 1A;autosomal dominant;CDCD1;CDDC;CMD1A;CMT2B1;EMD2;FPL;FPLD;FPLD2;HGPS;IDC;LAMIN A;lamin A/C;Lamin A/C like 1;Lamin;LAMIN C;Lamin-A/C;LDP1;LFP;LGMD1B;Limb girdle muscular dystrophy 1B;autosomal dominant;LMN 1;LMN A;LMN C;LMN1;LMNA;LMNA_HUMAN;LMNC;LMNL1;Prelamin A/C;PRO1;Renal carcinoma antigen NY REN 32;Renal carcinoma antigen NY-REN-32;Renal carcinoma antigen NYREN32. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human LMNA protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Lamin A/C Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Lamin A/C. It has been validated for Western Blot, Immunofluorescence and reacts with Human.
Validated Applications
| Target | Lamin A/C |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of Lamin A/C and does not cross-react with related proteins. |
| Molecular Weight | Observed: 74/63 kDa |
| UniProt / Swiss-Prot | P02545 (Human) | P48678 (Mouse) |
Recommended dilutions: WB 1:1000;ICC 1:200;IF 1:50-200
Immunogen / Antigen
Purified recombinant human LMNA protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence. Recommended dilutions: WB 1:1000;ICC 1:200;IF 1:50-200
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
