| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | ABC20;ABCB1;ATP binding cassette, sub family B;MDR/TAP;, member 1;ATP-binding cassette sub-family B member 1;CD243;CLCS;Colchicin sensitivity;Doxorubicin resistance;GP170;MDR1;MDR1_HUMAN;Multidrug resistance 1;Multidrug resistance protein 1;P glycoprotein 1;P gp;P-glycoprotein 1;PGY1 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human MDR1 AA range: 600-700 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® MDR1 (ABT252) Mouse Monoclonal Antibody (WM1459) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against MDR1. It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human, Mouse.
Validated Applications
| Target | MDR1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT252 |
| Isotype | IgG1, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human MDR1 protein. |
| Molecular Weight | Calculated: 141 kDa | Observed: 120 kDa |
| UniProt / Swiss-Prot | P08183 (Human) | P43245 (Rat) |
Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human MDR1 AA range: 600-700
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.
Scientific Background
MDR-1, also known as P-170, is a membrane glycoprotein encoded by MDR gene. Its main function is to quickly pump cytotoxic drugs out of cells by ATP. Its expression level is related to the permeability of cell membrane, intracellular drug concentration and the degree of drug resistance. It is mainly used in the study of tumor drug resistance.
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT252.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
