| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | ABC20;ABCB1;ATP binding cassette, sub family B;MDR/TAP;, member 1;ATP-binding cassette sub-family B member 1;CD243;CLCS;Colchicin sensitivity;Doxorubicin resistance;GP170;MDR1;MDR1_HUMAN;Multidrug resistance 1;Multidrug resistance protein 1;P glycoprotein 1;P gp;P-glycoprotein 1;PGY1 |
| Gene ID | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Synthesized peptide derived from human MDR1 AA range: 600-700 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® MDR1 (ABT252) Mouse Monoclonal Antibody (WM1749) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against MDR1. It has been validated for Immunohistochemistry, ELISA and reacts with Human, Mouse.
Validated Applications
| Target | MDR1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT252 |
| Isotype | IgG1, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse |
| Applications | Immunohistochemistry, ELISA |
| Purification | Affinity Purified |
| Specificity | The antibody can specifically recognize human MDR1 protein. |
| Molecular Weight | Calculated: 141 kDa | Observed: 120 kDa |
| UniProt / Swiss-Prot | P08183 (Human) | P43245 (Rat) |
Recommended dilutions: IHC 1:200-400;ELISA 1:500-5000
Immunogen / Antigen
Synthesized peptide derived from human MDR1 AA range: 600-700
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.
Scientific Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Immunohistochemistry, ELISA. Recommended dilutions: IHC 1:200-400;ELISA 1:500-5000
Confirmed reactivity: Human, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT252.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
