| Field | Specification |
|---|---|
| Target | |
| Alternative names | AW212142;dual specificity mitogen activated protein kinase kinase 3;Dual specificity mitogen activated protein kinase kinase 6;Dual specificity mitogen-activated protein kinase kinase 3;MAP kinase kinase 3;MAP kinase kinase 6;map2k3;MAP2K6;MAPK ERK kinase 3;MAPK/ERK kinase 3;MAPK/ERK kinase 6;MAPKK 3;MAPKK 6;MAPKK3;MAPKK6;MEK 3;MEK 6;MEK3;Mitogen activated protein kinase kinase 3;Mitogen activated protein kinase kinase 6;MKK 3;MKK3;MKK6;mMKK3b;MP2K3_HUMAN;PRKMK 3;PRKMK3;PRKMK6;Protein kinase, mitogen activated, kinase 6;MAP kinase kinase 6;protein kinase, mitogen-activated, kinase 3;SAPK kinase 2;SAPKK 2;SAPKK 3;SAPKK-2;SAPKK2;SAPKK3;Stress activated protein kinase kinase 2;Stress activated protein kinase kinase 3;Stress-activated protein kinase kinase 2. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human MKK6 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® MKK3/6 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against MKK3/6. It has been validated for Western Blot, Immunoprecipitation and reacts with Human, Rat.
Validated Applications
| Target | MKK3/6 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Rat |
| Applications | Western Blot, Immunoprecipitation |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of MKK3 and MKK6 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 40 kDa |
| UniProt / Swiss-Prot | P52564 (Human) | P70236 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human MKK6 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Rat. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Western Blot, Immunoprecipitation. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
