| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | MSH2;DNA mismatch repair protein Msh2;hMSH2;MutS protein homolog 2 |
| Gene ID | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® MSH2 (ABT022) Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against MSH2. It has been validated for Immunohistochemistry, Western Blot and reacts with Human.
Validated Applications
| Target | MSH2 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT022 |
| Isotype | IgG1, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Immunohistochemistry, Western Blot |
| Purification | Protein G |
| Specificity | This antibody detects endogenous levels of MSH2 protein. |
| Molecular Weight | Calculated: 105 kDa | Observed: 105 kDa |
| UniProt / Swiss-Prot | P43246 (Human) | P43247 (Mouse) | P54275 (Rat) |
Recommended dilutions: IHC 1:100-1:400;WB 1:2000-1:10000
Immunogen / Antigen
DNA mismatch repair protein Msh2
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot. Recommended dilutions: IHC 1:100-1:400;WB 1:2000-1:10000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT022.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
