| Field | Specification |
|---|---|
| Target | |
| Alternative names | NOG;NOGG_HUMAN;Noggin;SYM 1;SYM1;Symphalangism 1;proximal;Synostoses;multiple;syndrome 1;SYNS 1;SYNS1. |
| Gene ID | |
| Host | |
| Clonality | |
| Applications | |
| Immunogen | Purified recombinant human Noggin protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Noggin Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Noggin. It has been validated for Western Blot, Immunofluorescence and reacts with the listed species.
Validated Applications
| Target | Noggin |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Applications | Western Blot, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | Transfected Only. |
| Molecular Weight | Observed: 26 kDa |
| UniProt / Swiss-Prot | Q13253 (Human) | P97466 (Mouse) |
Recommended dilutions: WB 1:1000;ICC 1:100
Immunogen / Antigen
Purified recombinant human Noggin protein fragments expressed in E.coli.
Scientific Background
The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu
Safety & Handling
This antibody is validated for Western Blot, Immunofluorescence. Recommended dilutions: WB 1:1000;ICC 1:100
Confirmed reactivity: the listed species. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
