| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | NUP98;ADAR2;Nuclear pore complex protein Nup98-Nup96 |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human Nup98 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® NUP98 Mouse Monoclonal Antibody (WM0512) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against NUP98. It has been validated for Western Blot and reacts with Human, Mouse, Dog.
Validated Applications
| Target | NUP98 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Dog |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | Nup98 Monoclonal Antibody detects endogenous levels of Nup98 protein. |
| Molecular Weight | Calculated: 198 kDa |
| UniProt / Swiss-Prot | P52948 (Human) |
Recommended dilutions: WB 1:1000-1:2000;Not yet tested in other applications.
Immunogen / Antigen
Purified recombinant human Nup98 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Dog. Confirm suitability for untested species before use.
Scientific Background
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000-1:2000;Not yet tested in other applications.
Confirmed reactivity: Human, Mouse, Dog. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
