| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Cadherin associated Src substRate;Cadherin-associated Src substRate;CAS;Catenin;cadherin associated protein;delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;delta 1 Catenin;KIAA0384;p120;P120 CAS;p120 catenin;P120 CTN;p120;cas;p120;ctn;P120CAS;P120CTN |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human p120 catenin AA range: 600-700 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® p120 catenin (ABT-p120) Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against p120 Catenin. It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human, Mouse, Rat.
Validated Applications
| Target | p120 Catenin |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT-p120 |
| Isotype | IgG2b, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human p120 catenin protein. In western blotting of Hela, A431 and HEK293 cell lysates, the antibody can label a band with molecular weight around 100~110 kDa. |
| Molecular Weight | Calculated: 108 kDa | Observed: 110 kDa |
| UniProt / Swiss-Prot | O60716 (Human) |
Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human p120 catenin AA range: 600-700
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
α- Catenin、 β- Catenin、 γ- catenin and p120 catenin are members of the connexin family and mediate intercellular adhesion together with E-cadherin. P120 catenin binds to the near membrane region of E-cadherin to form a complex, which is stable and closely linked. In lobular breast cancer, E-cadherin deficiency resulted in the accumulation of p120 catenin in the cytoplasm, while in ductal breast cancer, p120 catenin in the membrane decreased and there was no accumulation of p120 catenin in the cytoplasm. Therefore, it can be used to distinguish lobular carcinoma from ductal carcinoma. Studies have shown that p120 catenin in the cytoplasm of gastric and colon cancer is related to poor adhesion of cancer cells.
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT-p120.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
