| Field | Specification |
|---|---|
| Alternative Names | KL-la |
| Clonality | |
| Conjugate | |
| Formulation | |
| Host | |
| Immunogen | polypeptide |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Pan-L-Lactyllysine Rabbit mAb (Recombinant Monoclonal, Clone W-R81) is a recombinant monoclonal antibody raised in Rabbit that specifically recognizes L-Lactyllysine (Lysine lactylation [Lys(K)]). It is designed for detection and analysis of the Lysine lactylation [Lys(K)] post-translational modification across research applications.
L-Lactyllysine (abbreviated as Kla) is a novel lysine acylation-type post-translational modification. It is formed by the covalent attachment of an L-lactyl group to lysine residues, mainly mediated by lactoyl-CoA. Kla is widely distributed on both histone and non-histone proteins, and participates in chromatin remodeling, gene transcription regulation, cellular metabolism, and inflammatory responses. Studies have shown that L-lactylation is closely associated with tumor metabolic reprogramming, hypoxia stress, immune regulation, and various disease processes, serving as a key mechanism linking cellular metabolism and epigenetic regulation.
Validated Applications
| Application | Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, Immunoprecipitation, ChIP |
|---|---|
| Recommended Dilution | WB 1:500-1:1000, IHC-P 1:200-1:1000, ICC/IF 1:50-1:100, FC 1:50-1:100, IP 1:25-1:100, ChIP 6 ug per 5×10⁶ cells |
| Host | Rabbit |
| Clonality | Recombinant Monoclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Conjugate | Unconjugated |
| Purification | Protein A |
| Molecular Weight | Calculated: Multiple | Observed: Multiple |
Immunogen / Antigen
polypeptide
Reactivity Notes
This antibody shows reactivity with Human, Mouse, Rat. It targets the Lysine lactylation [Lys(K)] modification and is suitable for Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, Immunoprecipitation, ChIP.
Safety & Handling
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Explore other UcallM Biosciences post-translational modification antibodies available through BioHippo.
It is validated for Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, Immunoprecipitation, ChIP. Recommended dilutions: WB 1:500-1:1000, IHC-P 1:200-1:1000, ICC/IF 1:50-1:100, FC 1:50-1:100, IP 1:25-1:100, ChIP 6 ug per 5×10⁶ cells.
Use WB 1:500-1:1000, IHC-P 1:200-1:1000, ICC/IF 1:50-1:100, FC 1:50-1:100, IP 1:25-1:100, ChIP 6 ug per 5×10⁶ cells. Optimal dilution should be determined empirically for your sample and detection system.
This is a pan-modification antibody recognizing L-Lactyllysine (Lysine lactylation [Lys(K)]); reactivity: Human, Mouse, Rat.
The recombinant monoclonal antibody (Rabbit host) was raised against polypeptide.
This product is supplied unconjugated. Contact BioHippo for custom conjugation or format options.
Store at -20°C. Avoid repeated freeze-thaw cycles | Stable for 12 months from date of receipt / reconstitution.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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