| Field | Specification |
|---|---|
| Clonality | |
| Conjugate | |
| Host | |
| Molecular Weight | |
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Product Overview
U-Blot® Pan-O-GlcNAc Rabbit mAb (Monoclonal) is a monoclonal antibody raised in Rabbit that specifically recognizes O-GlcNAc (O-GlcNAcylation [Ser(S)/Thr(T)]). It is designed for detection and analysis of the O-GlcNAcylation [Ser(S)/Thr(T)] post-translational modification across research applications.
O-GlcNAc (short for O-linked β-N-acetylglucosamine) is a reversible enzymatic post-translational modification found on serine and threonine residues of nucleocytoplasmic proteins. The modification is characterized by a β-glycosidic bond between the hydroxyl group of serine or threonine side chains and N-acetylglucosamine (GlcNAc).It is widely involved in the regulation of diverse cellular processes, including transcription, cell cycle, signal transduction, and stress response. Dysregulation of O-GlcNAcylation has been closely linked to cancer, neurodegeneration, diabetes, and inflammatory diseases. Notably, elevated O-GlcNAc levels in many cancers have been reported to suppress apoptosis by inhibiting caspase activation.
Validated Applications
| Application | Western Blot |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Molecular Weight | Calculated: Multiple | Observed: Multiple |
Reactivity Notes
This antibody shows reactivity with multiple species. It targets the O-GlcNAcylation [Ser(S)/Thr(T)] modification and is suitable for Western Blot.
Safety & Handling
Related Products
Explore other UcallM Biosciences post-translational modification antibodies available through BioHippo.
It is validated for Western Blot. Recommended dilutions: application-dependent (see datasheet).
Use application-dependent (see datasheet). Optimal dilution should be determined empirically for your sample and detection system.
This is a pan-modification antibody recognizing O-GlcNAc (O-GlcNAcylation [Ser(S)/Thr(T)]); reactivity: multiple species.
The monoclonal antibody (Rabbit host) was raised against a synthetic peptide corresponding to the modified residue.
This product is supplied unconjugated. Contact BioHippo for custom conjugation or format options.
Store at -20°C; avoid repeated freeze-thaw cycles.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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