| Field | Specification |
|---|---|
| Alternative Names | Kpyru |
| Clonality | |
| Conjugate | |
| Formulation | |
| Host | |
| Immunogen | polypeptide |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Pan-Pyruvyllysine Rabbit pAb is a polyclonal antibody raised in Rabbit that specifically recognizes Pyruvyllysine (Lysine pyruvylation). It is designed for detection and analysis of the Lysine pyruvylation post-translational modification across research applications.
Lysine pyruvylation is a novel type of protein post-translational modification first identified in 2026. Pyruvate is an intermediate metabolite of glycolysis. Hyperglycemic conditions or aberrant activation of glycolysis lead to pyruvate accumulation, which can undergo nucleophilic addition reaction with lysine residues. Recent research advances have revealed that serum pyruvate levels are elevated in hyperglycemic individuals, accompanied by increased lysine pyruvylation of STAT1. This modification markedly reduces the expression of interferon-stimulated genes (ISGs), thereby impairing type I interferon (IFN-I)-mediated antiviral immune responses and further increasing susceptibility to viral infections in hyperglycemic populations. Meanwhile, this study provides a novel strategy to restore the therapeutic efficacy of IFN-I-based antiviral therapy in individuals with elevated blood glucose. Additionally, lysine pyruvylation may exert crucial regulatory roles in tumor metabolism, inflammation, immune disorders and other related research fields.
Validated Applications
| Application | Western Blot |
|---|---|
| Recommended Dilution | WB 1:500 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Species Independent |
| Conjugate | Unconjugated |
| Purification | Protein A |
| Molecular Weight | Calculated: Multiple | Observed: Multiple |
Immunogen / Antigen
polypeptide
Reactivity Notes
This antibody shows reactivity with Species Independent. It targets the Lysine pyruvylation modification and is suitable for Western Blot.
Safety & Handling
Related Products
Explore other UcallM Biosciences post-translational modification antibodies available through BioHippo.
It is validated for Western Blot. Recommended dilutions: WB 1:500.
Use WB 1:500. Optimal dilution should be determined empirically for your sample and detection system.
This is a pan-modification antibody recognizing Pyruvyllysine (Lysine pyruvylation); reactivity: Species Independent.
The polyclonal antibody (Rabbit host) was raised against polypeptide.
This product is supplied unconjugated. Contact BioHippo for custom conjugation or format options.
Store at -20°C. Avoid repeated freeze-thaw cycles | Stable for 12 months from date of receipt / reconstitution.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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