| Field | Specification |
|---|---|
| Alternative Names | Rme2 (sy) |
| Clonality | |
| Conjugate | |
| Formulation | |
| Host | |
| Immunogen | polypeptide |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Pan-Symmetric Di-Methyl Arginine Rabbit pAb is a polyclonal antibody raised in Rabbit that specifically recognizes Symmetric Di-Methyl Arginine (Symmetric dimethylation of arginine [Arg(R)]). It is designed for detection and analysis of the Symmetric dimethylation of arginine [Arg(R)] post-translational modification across research applications.
Histones and non-histone proteins are subjected to a variety of enzyme-catalyzed post-translational modifications, including acetylation, methylation, phosphorylation and ubiquitination. Symmetric dimethyl arginine (SDMA) is an important arginine methylation mark catalyzed primarily by type II protein arginine methyltransferases. It is widely distributed in eukaryotic cells and abundantly present in chromatin proteins, RNA-binding factors and signal transduction molecules. SDMA participates in the regulation of chromatin remodeling, gene transcription, RNA splicing, DNA damage response and cell fate determination. Dysregulation of symmetric arginine dimethylation is closely linked to inflammation, tumorigenesis, cardiovascular disorders and neurodegenerative diseases, serving as a critical epigenetic marker for biological mechanism research and disease pathological study.
Validated Applications
| Application | Western Blot, Immunofluorescence |
|---|---|
| Recommended Dilution | WB 1:500-1000, ICC/IF 1:50 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Conjugate | Unconjugated |
| Purification | Antibodies are purified by protein A-conjugated agarose followed by Rme2 (sy) peptide agarose affinity chromatography. |
| Molecular Weight | Calculated: Multiple | Observed: Multiple |
Immunogen / Antigen
polypeptide
Reactivity Notes
This antibody shows reactivity with Human, Mouse, Rat. It targets the Symmetric dimethylation of arginine [Arg(R)] modification and is suitable for Western Blot, Immunofluorescence.
Safety & Handling
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It is validated for Western Blot, Immunofluorescence. Recommended dilutions: WB 1:500-1000, ICC/IF 1:50.
Use WB 1:500-1000, ICC/IF 1:50. Optimal dilution should be determined empirically for your sample and detection system.
This is a pan-modification antibody recognizing Symmetric Di-Methyl Arginine (Symmetric dimethylation of arginine [Arg(R)]); reactivity: Human, Mouse, Rat.
The polyclonal antibody (Rabbit host) was raised against polypeptide.
This product is supplied unconjugated. Contact BioHippo for custom conjugation or format options.
Store at -20°C. Avoid repeated freeze-thaw cycles | Stable for 12 months from date of receipt / reconstitution.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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