| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | Proprotein convertase subtilisin/kexin type 9;Neural apoptosis-regulated convertase 1;NARC-1;Proprotein convertase 9;PC9;Subtilisin/kexin-like protease PC9 |
| Gene ID | |
| Host | |
| Clone | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Synthesized peptide derived from human PCSK9 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® PCSK9 Mouse Monoclonal Antibody (5G4) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against PCSK9. It has been validated for Immunohistochemistry and reacts with Human.
Validated Applications
| Target | PCSK9 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 5G4 |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Immunohistochemistry |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of PCSK9 at Human, Mouse,Rat |
| Molecular Weight | Observed: 74 kDa |
| UniProt / Swiss-Prot | Q8NBP7 (Human) | Q80W65 (Mouse) | P59996 (Rat) |
Recommended dilutions: IHC1:50-200
Immunogen / Antigen
Synthesized peptide derived from human PCSK9
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Safety & Handling
This antibody is validated for Immunohistochemistry. Recommended dilutions: IHC1:50-200
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone 5G4.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
