| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | CD279;CD279 antigen;hPD 1;hPD l;hPD-1;hSLE1;PD 1;PD-1;PD1;PDCD 1;PDCD1;PDCD1_HUMAN;Programmed cell death 1;Programmed cell death 1 protein;Programmed cell death protein 1;Protein PD 1;Protein PD-1;SLEB2;Systemic lupus erythematosus susceptibility 2 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human PD-1 AA range: 1-100 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® PD-1 (ABT-PD1) Mouse Monoclonal Antibody (WM1443) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against PD1. It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human.
Validated Applications
| Target | PD1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT-PD1 |
| Isotype | IgG1, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human PD-1 protein. |
| Molecular Weight | Calculated: 32 kDa | Observed: 56 kDa |
| UniProt / Swiss-Prot | Q15116 (Human) |
Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human PD-1 AA range: 1-100
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
Programmed death-1 (PD-1) is an important immunosuppressive molecule. It is a member of CD28 superfamily. It is mainly expressed in germinal center related helper T cells and CD8 positive T cells. It includes tyrosine based inhibitory motif immune receptors, and plays an important role in peripheral immune tolerance mechanism and autoimmune diseases. PD-1 is a receptor for PD-L1 and PD-L2. Immune regulation targeting PD-1 is of great significance in anti-tumor, anti infection, anti autoimmune diseases and organ transplantation survival.
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT-PD1.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
