| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Platelet-derived growth factor receptor beta;PDGF-R-beta;PDGFR-beta;Beta platelet-derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1;PDGFR-1;CD antigen CD140b |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human PDGFRb (Phospho-Tyr857) |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® PDGFRb (Phospho Tyr857) Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against PDGFR-β. Recognizes Phospho. It has been validated for Immunohistochemistry, Immunofluorescence, Western Blot and reacts with Human, Mouse, Rat.
Validated Applications
| Target | PDGFR-β |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Immunohistochemistry, Immunofluorescence, Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous phospho levels of PDGFRb (Phospho-Tyr857) at Human:Y857, Mouse:Y856, Rat:Y856 |
| Molecular Weight | Observed: 135-180 kDa |
| UniProt / Swiss-Prot | P09619 (Human) |
Recommended dilutions: IHC 1:50-200;WB 1:500-2000;IF 1:50-200
Immunogen / Antigen
Synthesized peptide derived from human PDGFRb (Phospho-Tyr857)
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Immunohistochemistry, Immunofluorescence, Western Blot. Recommended dilutions: IHC 1:50-200;WB 1:500-2000;IF 1:50-200
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
