| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | MBTPS2;S2P;Membrane-bound transcription factor site-2 protease;Endopeptidase S2P;Sterol regulatory element-binding proteins intramembrane protease;SREBPs intramembrane protease |
| Gene ID | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MBTPS2. AA range:301-350 |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Concentration | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® S2P Rabbit Polyclonal Antibody is a rabbit polyclonal antibody from UcallM Biosciences Inc, raised against S2P. It has been validated for Western Blot, Immunoprecipitation, Immunofluorescence, ELISA and reacts with Human, Mouse, Rat.
Validated Applications
| Target | S2P |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Western Blot, Immunoprecipitation, Immunofluorescence, ELISA |
| Purification | Affinity Purified |
| Specificity | S2P Polyclonal Antibody detects endogenous levels of S2P protein. |
| Molecular Weight | Calculated: 57 kDa |
| UniProt / Swiss-Prot | O43462 (Human) | Q8CHX6 (Mouse) |
Recommended dilutions: WB 1:500-2000;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
Immunogen / Antigen
The antiserum was produced against synthesized peptide derived from human MBTPS2. AA range:301-350
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]
Safety & Handling
This antibody is validated for Western Blot, Immunoprecipitation, Immunofluorescence, ELISA. Recommended dilutions: WB 1:500-2000;IF 1:200-1:1000;ELISA 1:20000;Not yet tested in other applications.
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
