| Field | Specification |
|---|---|
| Target | |
| Alternative names | 70 kda SHP1L protein;70Z-SHP;HCP;HCPH;Hematopoietic cell phosphatase;Hematopoietic cell protein tyrosine phosphatase;Hematopoietic cell protein-tyrosine phosphatase;HPTP1C;Protein tyrosine phosphatase 1C;Protein tyrosine phosphatase non receptor type 6;Protein tyrosine phosphatase SHP1;Protein-tyrosine phosphatase 1C;protein-tyrosine phosphatase SHP 1;Protein-tyrosine phosphatase SHP-1;PTN6_HUMAN;PTP 1C;PTP-1C;PTP1C;PTPN6;SH PTP 1;SH PTP1;SH-PTP1;SHP 1;SHP 1L;SHP1;SHP1L;tyrosine protein phosphatase non receptor type 6;Tyrosine-protein phosphatase non-receptor type 6. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human SHP-1 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® SHP-1 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against SHP-1. It has been validated for Western Blot, Immunoprecipitation and reacts with Human.
Validated Applications
| Target | SHP-1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot, Immunoprecipitation |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of SHP-1 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 68 kDa |
| UniProt / Swiss-Prot | P29350 (Human) | P29351 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human SHP-1 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul
Safety & Handling
This antibody is validated for Western Blot, Immunoprecipitation. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
