| Field | Specification |
|---|---|
| Target | |
| Antigen | |
| Alternative names | SOCS3;CIS3;SSI3;Suppressor of cytokine signaling 3;SOCS-3;Cytokine-inducible SH2 protein 3;CIS-3;STAT-induced STAT inhibitor 3;SSI-3 |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human SOCS-3 (N-terminus) protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® SOCS-3 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against SOCS-3. It has been validated for Western Blot, Immunohistochemistry, Immunofluorescence and reacts with Human, Pig.
Validated Applications
| Target | SOCS-3 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Pig |
| Applications | Western Blot, Immunohistochemistry, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | SOCS-3 Monoclonal Antibody detects endogenous levels of SOCS-3 protein. |
| Molecular Weight | Calculated: 25 kDa |
| UniProt / Swiss-Prot | O14543 (Human) | O35718 (Mouse) |
Recommended dilutions: WB 1:1000-1:2000;IHC 1:500-1:1000;IF 1:50-200
Immunogen / Antigen
Purified recombinant human SOCS-3 (N-terminus) protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Pig. Confirm suitability for untested species before use.
Scientific Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Western Blot, Immunohistochemistry, Immunofluorescence. Recommended dilutions: WB 1:1000-1:2000;IHC 1:500-1:1000;IF 1:50-200
Confirmed reactivity: Human, Pig. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
