| Field | Specification |
|---|---|
| Target | |
| Alternative names | 2310012M03Rik;3'-Tab1;MAP3K7IP 1;MAP3K7IP1;MGC57664;Mitogen activated protein kinase kinase kinase 7 interacting protein 1;Mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TAB 1;TAB1;TAB1_HUMAN;TAK1 binding protein 1;TAK1-binding protein 1;TGF beta activated kinase 1 binding protein 1;TGF-beta activated kinase 1/MAP3K7 binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1-binding protein 1;Transforming growth factor beta activated kinase binding protein 1. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® TAB1(N-term) Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against TAB1(N-term). It has been validated for Western Blot and reacts with Human.
Validated Applications
| Target | TAB1(N-term) |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of TAB1(N-terminus) and does not cross-react with related proteins. |
| Molecular Weight | Observed: 55 kDa |
| UniProt / Swiss-Prot | Q15750 (Human) | Q8CF89 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000
Confirmed reactivity: Human. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
