| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | TBL1XR1;IRA1;TBLR1;F-box-like/WD repeat-containing protein TBL1XR1;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1-related protein 1;Transducin beta-like 1X-related protein 1 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Purified recombinant human TBL1XR1 protein fragments expressed in E.coli. |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® TBL1XR1 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against TBLR1. It has been validated for Western Blot, Immunohistochemistry, Immunofluorescence and reacts with Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish.
Validated Applications
| Target | TBLR1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish |
| Applications | Western Blot, Immunohistochemistry, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | TBL1XR1 Monoclonal Antibody detects endogenous levels of TBL1XR1 protein. |
| Molecular Weight | Calculated: 56 kDa |
| UniProt / Swiss-Prot | Q9BZK7 (Human) | Q8BHJ5 (Mouse) |
Recommended dilutions: WB 1:1000-1:2000;IHC 1:500-1:1000;IF 1:100-1:500;Not yet tested in other applications.
Immunogen / Antigen
Purified recombinant human TBL1XR1 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish. Confirm suitability for untested species before use.
Scientific Background
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Safety & Handling
This antibody is validated for Western Blot, Immunohistochemistry, Immunofluorescence. Recommended dilutions: WB 1:1000-1:2000;IHC 1:500-1:1000;IF 1:100-1:500;Not yet tested in other applications.
Confirmed reactivity: Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
