| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | C21;DC42;F box like/WD repeat containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1XR1;FLJ12894;IRA1;Nuclear receptor corepressor/HDAC3 complex subunit;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1 related protein 1;TBL1-related protein 1;TBL1R_HUMAN;TBL1XR1;Transducin;beta;like 1 X linked receptor 1;Transducin beta like 1X related protein 1;Transducin beta-like 1X-related protein 1. |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Purified recombinant human TBLR1 protein fragments expressed in E.coli. |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® TBLR1 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against TBLR1. It has been validated for Western Blot, Immunohistochemistry, Immunofluorescence and reacts with Human, Mouse.
Validated Applications
| Target | TBLR1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse |
| Applications | Western Blot, Immunohistochemistry, Immunofluorescence |
| Purification | Affinity Purified |
| Specificity | This antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins. |
| Molecular Weight | Observed: 60 kDa |
| UniProt / Swiss-Prot | Q9BZK7 (Human) | Q8BHJ5 (Mouse) |
Recommended dilutions: WB 1:1000;ICC 1:200 1:500-1:1000
Immunogen / Antigen
Purified recombinant human TBLR1 protein fragments expressed in E.coli.
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse. Confirm suitability for untested species before use.
Scientific Background
This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Safety & Handling
This antibody is validated for Western Blot, Immunohistochemistry, Immunofluorescence. Recommended dilutions: WB 1:1000;ICC 1:200 1:500-1:1000
Confirmed reactivity: Human, Mouse. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
