| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | AV026640;BCH;Benign chorea;BHC;Homeobox protein NK 2 homolog A;Homeobox protein NK-2 homolog A;Homeobox protein Nkx 2.1;Homeobox protein Nkx-2.1;Homeobox protein Nkx2.1;NK 2;NK 2 homolog A;NK2;NK2 homeobox 1;NK2, drosophila, homolog of, A;NK2.1, Mouse, homolog of;Nkx 2 1;NKX 2.1;NKX 2A;NKX2 1;Nkx2-1;NKX2.1;NKX21_HUMAN;NKX2A;T EBP;T/EBP;TEBP;Thyroid nuclear factor 1;Thyroid nuclear factor;Thyroid specific enhancer binding protein;Thyroid transcription factor 1;Tin man;Tinman;TITF 1;TITF1;TTF 1;TTF-1;TTF1 |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Synthesized peptide derived from human TTF1 AA range: 50-150 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® TTF1 (ABT237) Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against TTF-1. It has been validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA and reacts with Human, Mouse, Rat.
Validated Applications
| Target | TTF-1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | ABT237 |
| Isotype | IgG1, Kappa |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Immunohistochemistry, Western Blot, Immunofluorescence, ELISA |
| Purification | Protein G |
| Specificity | The antibody can specifically recognize human TTF1 protein. |
| Molecular Weight | Calculated: 39 kDa | Observed: 39 kDa |
| UniProt / Swiss-Prot | P43699 (Human) | P50220 (Mouse) | P23441 (Rat) |
Recommended dilutions: IHC 1:50-200;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Immunogen / Antigen
Synthesized peptide derived from human TTF1 AA range: 50-150
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
Thyroid transcription factor 1 (TTF-1) is a nuclear protein with a molecular weight of 38-40 kDa. It is the basic material for thyroid differentiation and the regulation of thyroglobulin secretion. It can promote the transport of thyroid peroxidase and iodine / sodium. TTF-1 is mainly distributed in type II alveolar epithelium, respiratory epithelium and Clara cells of thyroid and lung in adult tissues, but it is not expressed in type I alveolar epithelium. It is mainly used for the diagnosis of small cell lung cancer, the differential diagnosis of primary lung adenocarcinoma from metastatic adenocarcinoma, and the differential diagnosis of lung cancer from malignant mesothelioma and paraganglioma of pleura.
Safety & Handling
This antibody is validated for Immunohistochemistry, Western Blot, Immunofluorescence, ELISA. Recommended dilutions: IHC 1:50-200;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone ABT237.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
