| Field | Specification |
|---|---|
| Target | |
| Alternative names | Int 4;INT4;MGC131950;MGC138321;MGC138323;Proto-oncogene Int-4 homolog;Proto-oncogene Wnt-3;wingless type MMTV integration site family member 3;Wnt 3 proto oncogene protein;WNT 3 proto oncogene protein precursor;wnt3;WNT3_HUMAN. |
| Gene ID | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Purified recombinant human Wnt3 protein fragments expressed in E.coli. |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Cellular localization | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Wnt3 Mouse Monoclonal Antibody is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against Wnt3. It has been validated for Western Blot and reacts with the listed species.
Validated Applications
| Target | Wnt3 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Conjugate | Unconjugated |
| Reactivity | Transfected |
| Applications | Western Blot |
| Purification | Affinity Purified |
| Specificity | Transfected Only. |
| Molecular Weight | Observed: 40 kDa |
| UniProt / Swiss-Prot | P56703 (Human) | P17553 (Mouse) |
Recommended dilutions: WB 1:1000
Immunogen / Antigen
Purified recombinant human Wnt3 protein fragments expressed in E.coli.
Scientific Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
Safety & Handling
This antibody is validated for Western Blot. Recommended dilutions: WB 1:1000
Confirmed reactivity: the listed species. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
