| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble up to 100 mM in 1 eq. NaOH. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 4-[[3-[(2S)-2-amino-2-carboxyethyl]-2,6-dioxopyrimidin-1-yl]methyl]benzoic acid.
- Also known as: 3-CBW
- CAS number: 544697-47-4
- Molecular formula: C15H15N3O6.
- Purity: >99%
- Concentration: 10-200 µM.
- Form: Lyophilized powder.
- Solubility: Soluble up to 100 mM in 1 eq. NaOH. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble up to 100 mM in 1 eq. NaOH. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: AMPA, Kainate receptors
- Source: Synthetic
- Activity: UBP 282 is an antagonist of AMPA and kainate glutamate receptors. It reduces the AMPA-mediated fast component of dorsal root-evoked ventral root potential with IC50 of 10.3 µM, and fully inhibits AMPA-evoked responses in neonatal motoneurons at 200 µM. It differentially antagonizes kainate-induced responses in dorsal root C-fibres with pA2 of 4.96, but not in spinal neonatal rat motoneurons at 200 µM1,2.
- Alternative names: 3-CBW
Scientific background
UBP 282 (3-CBW) is a synthetic willardiine analogue that acts as an antagonist of AMPA and Kainate glutamate receptors. The compound fully inhibits AMPA-evoked responses in neonatal motoneurons at 200 µM and reduces the AMPA-mediated fast component of dorsal root-evoked ventral root potential with IC50 value of 10.3 µM1,2.The ionotropic glutamate AMPA receptors (AMPARs) are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. This function is essential for synaptic plasticity and learning and memory3,4.Kainate receptors (KARs) are highly expressed in the developing brain, where they are tonically activated to modulate synaptic transmission, network excitability, and synaptogenesis5.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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