| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C30H44N6O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
UNC3133 is an orally active, only limitedly selective inhibitor of MerTK, with an IC50 of 3.0 nM. It also inhibits Axl, Tyro3 and Flt3 kinases, with IC50 values of 17 nM, 31 nM and 6.8 nM, respectively, and it is applicable to research on inflammatory diseases and cancers[1]. It has a molecular formula of C30H44N6O and a molecular weight of 504.71 g/mol.
Physical & Chemical Properties
| CAS Number | 2011034-35-6 |
|---|---|
| Molecular Formula | C30H44N6O |
| Molecular Weight | 504.71 g/mol |
| SMILES | OC(CCCCCCCN1)CCCCN2C3=NC1=NC=C3C(C4=CC=C(C=C4)CN5CCN(CC5)C)=C2 |
| Target | Axl, MERTK, Tyro3, FLT3 |
| Signaling Pathway | Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
Axl 17 nM (IC50) |
MERTK 3.0 nM (IC50) |
Tyro3 31 nM (IC50) |
FLT3 6.8 nM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
UNC3133 potently inhibits purified MerTK kinase activity (IC50 of 3.0 nM) and also inhibits Axl, Tyro3, and Flt3 kinases, yielding IC50 values of 17 nM, 31 nM, and 6.8 nM, respectively[1]. In HEK293 cells expressing an EGFR-MerTK chimeric protein, UNC3133 blocks EGF-stimulated MerTK phosphorylation (EC50 of 110 nM)[1]. UNC3133 shows limited kinome selectivity at 300 nM: more than 50% inhibition of 12 kinases, eight tyrosine kinases and four serine/threonine kinases among them (tested at 300 nM)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
