| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C17H28N2O |
| Purity | |
| SMILES | |
| Form | Oil |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
UNC3474 is a small-molecule ligand that binds 53BP1, engaging the aromatic methyl-lysine binding cage of 53BP1 TT with a dissociation constant (Kd) of 1.0 ± 0.3 μM. It inhibits recruitment of 53BP1 to DNA double-strand breaks (DSBs) by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1]. It is supplied as a light yellow to yellow oil (C17H28N2O, MW 276.42) at 98.56% purity.
Physical & Chemical Properties
| CAS Number | 1648707-79-2 |
|---|---|
| Molecular Formula | C17H28N2O |
| Molecular Weight | 276.42 g/mol |
| Purity | 98.56% |
| Appearance | Oil |
| Color | Light yellow to yellow |
| SMILES | O=C(C1=CC=CC(C(C)C)=C1)NCCCNC(C)(C)C |
| Signaling Pathway | Apoptosis |
| Solubility | In Vitro: DMSO: 100 mg/mL (361.77 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Pure form: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (361.77 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
53BP1TT-PN does not interact with UNC3474, in contrast to WT 53BP1TT[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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